A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents-Reference-Cited by-同舟云学术

A Review on the Advancements in the Field of Metal Complexes with Schiff Bases as Antiproliferative Agents

Published:2021-06-29 Issue:13 Volume:11 Page:6027
ISSN:2076-3417
Container-title:Applied Sciences
language:en
Short-container-title:Applied Sciences

Author:

Catalano Alessia^ORCID,Sinicropi Maria Stefania^ORCID,Iacopetta Domenico^ORCID,Ceramella Jessica^ORCID,Mariconda Annaluisa,Rosano Camillo^ORCID,Scali Elisabetta,Saturnino Carmela^ORCID,Longo Pasquale^ORCID

Abstract

Metal complexes play an essential role in pharmaceutical sciences for their multiple and important activities. Schiff bases are versatile pharmacophores able to form chelating complexes with several metals in different oxidation states. Complexes with Schiff bases are widely described in the literature for their multiple actions and numerous advantages, such as low cost and easy synthesis. They show multiple biological activities, including antimicrobial, antioxidant, antimalarial, antinflammatory and antitumor. Schiff bases may also form complexes with lanthanides and actinides acting as catalysts (e.g., in various synthetic processes) and antitumor agents. This review intends to extend on our previous paper regarding Schiff bases as antitumorals, highlighting the importance, in the field of the anticancer agents, of these tools as ligands of metal complexes.

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science

Link

https://www.mdpi.com/2076-3417/11/13/6027/pdf

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