Leprosy in Spain: A Descriptive Study of Admissions at Fontilles Sanatorium between 1909 and 2020

Author:

Juan Cristina1ORCID,Lledó Lourdes1ORCID,Torralba Miguel2ORCID,Gómez José Ramón3,Giménez Consuelo1ORCID

Affiliation:

1. Department of Biomedicine and Biotechnology, Faculty of Pharmacy, Alcalá University, 28805 Alcalá de Henares, Madrid, Spain

2. Internal Medicine Unit, Department of Medicine and Medical specialities, IDISCAM, Faculty of Medicine, Alcalá University, 28805 Alcalá de Henares, Madrid, Spain

3. Sanatorium San Francisco de Borja, Fontilles, 03791 Alicante, Spain

Abstract

Background: The study aimed to characterize patients with leprosy admitted to Fontilles throughout the 20th and 21st centuries, focusing on differences across three periods (I, II, and III). It also explored variables linked to patient survival. Methods: This was a retrospective descriptive study analyzing the medical records of Fontilles patients from 1909 to 2020. It assessed 26 clinical, sociodemographic, and temporal variables (n = 2652). Results: Most patients were male, single, multibacillary (MB), and farmers, from Andalusia and the Valencian Community. The origin of patients shifted over time towards being mostly foreign-born in period III. More than a half were previously admitted and had family members with leprosy. While leprosy reactions decreased over time, neurological symptoms were increasingly diagnosed. The age at onset, admission, and death increased progressively over time. The survival of patients with leprosy at Fontilles depended on the age at admission and the period. Conclusions: Improved knowledge, services, and awareness regarding leprosy led to increased age at onset and more favorable outcomes. The prolonged time between symptom onset and diagnosis indicates that leprosy is still a neglected disease. Although MB forms are more severe, leprosy classification did not significantly impact the survival rates of patients at Fontilles.

Publisher

MDPI AG

Reference51 articles.

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2. Scollard, D.M., and Gillis, T.P. (2023). Chapter 1.1. Epidemiology of Leprosy. International Texbook of Leprosy, American Leprosy Missions.

3. Loscalzo, J., Fauci, A., Kasper, D., Hauser, S., Longo, D., and Jameson, J. (2023). Capítulo 179: Lepra. Harrison. Principios de Medicina Interna, 21e, McGraw-Hill Education.

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5. Conejo, E. (1995). Estudio Epidemiológico de la Endemia Leprosa en Sevilla y su Provincia. [Ph.D. Dissertation, Universidad de Sevilla]. Available online: https://idus.us.es/bitstream/handle/11441/77781/TD%20C-157.pdf?sequence=1&isAllowed=y.

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