Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment: A Scoping Review-Reference-Cited by-同舟云学术

Immunobiology and Cytokine Modulation of the Pediatric Brain Tumor Microenvironment: A Scoping Review

Published:2023-07-18 Issue:14 Volume:15 Page:3655
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Budhiraja Shreya¹²³,Najem Hinda²³^ORCID,Tripathi Shashwat²³,Wadhawani Nitin R.⁴,Horbinski Craig²³,McCord Matthew³⁵^ORCID,Lenzen Alicia C.⁶,Heimberger Amy B.²³^ORCID,DeCuypere Michael¹²³^ORCID

Affiliation:

1. Division of Pediatric Neurosurgery, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA

2. Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

3. Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

4. Division of Pathology, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA

5. Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

6. Division of Hematology, Oncology, Neuro-Oncology, and Stem Cell Transplantation, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL 60611, USA

Abstract

Utilizing a Scoping Review strategy in the domain of immune biology to identify immune therapeutic targets, knowledge gaps for implementing immune therapeutic strategies for pediatric brain tumors was assessed. The analysis demonstrated limited efforts to date to characterize and understand the immunological aspects of tumor biology with an over-reliance on observations from the adult glioma population. Foundational knowledge regarding the frequency and ubiquity of immune therapeutic targets is an area of unmet need along with the development of immune-competent pediatric tumor models to test therapeutics and especially combinatorial treatment. Opportunities arise in the evolution of pediatric tumor classification from histological to molecular with targeted immune therapeutics.

Funder

NIH

Remission Alliance

Malnati Brain Tumor Institute

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/14/3655/pdf

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