Author:
Wang Xinming,Yang Chunlan,Körner Heinrich,Ge Chaoliang
Abstract
Tumor Necrosis Factor was one of the first cytokines described in the literature as a soluble mediator of cytotoxicity to tumors. Over the years, more extensive research that tried to employ Tumor Necrosis Factor in cancer treatments showed nevertheless that it mainly functioned as a proinflammatory cytokine. However, this did not stop the search for the holy grail of cancer research: A cytokine that could act as a one-stop treatment for solid tumors and lymphomas. This review will summarize the long experimental history of Tumor Necrosis Factor that caused the initial observations of a tumor necrotizing cytokine that could serve as a potential cancer treatment and discuss the current state of research into this side of the activities of Tumor Necrosis Factor.
Funder
National Natural Science Foundation of China
Anhui Provincial Natural Science Foundation
Open Fund of Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, P. R. of China
Clinical Science Foundation of Anhui Medical University
Cited by
6 articles.
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