Unveiling the Power of Anticancer Drug Screening: A Clinical Case Study Comparing the Effectiveness of Hollow Fiber Assay Microtube Array Membrane (MTAM-HFA) in Breast Cancer Patients

Author:

Tu Shih-Hsin12ORCID,Huang Wan-Ting3,Chew Chee Ho3,Chen Amanda Lin4,Chen Shou-Tung56,Chen Jin-Hua7,Hsieh Yi-Chen8ORCID,Chen Chien-Chung39

Affiliation:

1. Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan

2. Department of Surgery, Taipei Medical University Hospital, Taipei 11052, Taiwan

3. Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei 11052, Taiwan

4. Translational Autoinflammatory Disease Section (TADS), Laboratory of Clinical Immunology and Microbiology (LCIM), National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA

5. Comprehensive Breast Cancer Center, Changhua Christian Hospital, Changhua 50094, Taiwan

6. Department of Medical Research, Changhua Christian Hospital, Changhua 50094, Taiwan

7. Graduate Institute of Data Science, College of Management, Taipei Medical University, Taipei 11052, Taiwan

8. Ph.D. Program in Medical Neuroscience, Taipei Medical University, Taipei 250, Taiwan

9. Ph.D. Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei 250, Taiwan

Abstract

Breast cancer is a severe public health problem, and early treatment with powerful anticancer drugs is critical for success. The researchers investigated the clinical results of a novel screening tool termed Microtube Array Membrane Hollow Fiber Assay (MTAM-HFA) in breast cancer patients in this clinical investigation. In all trial participants, the MTAM-HFA was utilized to identify active medicines for the treatment of breast cancer. The MTAM-HFA was shown to be extremely useful in predicting patient response to anticancer medication therapy in this study. Furthermore, the substantial association between the MTAM-HFA screening outcome and the clinical outcome of the respective patients emphasizes the promise of this unique screening technology in discovering effective anticancer medication combinations for the treatment of breast cancer. These findings indicate that the MTAM-HFA has clinical significance and might be a valuable tool in the development of tailored therapy for cancer care. This study provides helpful information for physicians and scientists working on breast cancer therapy research. The potential benefits of employing MTAM-HFA to find accurate therapies for breast cancer patients might lead to enhanced personalized medicine approaches to cancer care, resulting in better patient outcomes. Overall, the MTAM-HFA screening approach has the potential to revolutionize customized cancer therapy, providing hope to both patients and physicians.

Funder

the National Science and Technology Council

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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