Affiliation:
1. Duke Cancer Institute, Durham, NC 27710, USA
Abstract
Cancer remains a leading cause of mortality worldwide, with metastasis significantly contributing to its lethality. The metastatic spread of tumor cells, primarily through the bloodstream, underscores the importance of circulating tumor cells (CTCs) in oncological research. As a critical component of liquid biopsies, CTCs offer a non-invasive and dynamic window into tumor biology, providing invaluable insights into cancer dissemination, disease progression, and response to treatment. This review article delves into the recent advancements in CTC research, highlighting their emerging role as a biomarker in various cancer types. We explore the latest technologies and methods for CTC isolation and detection, alongside novel approaches to characterizing their biology through genomics, transcriptomics, proteomics, and epigenetic profiling. Additionally, we examine the clinical implementation of these findings, assessing how CTCs are transforming the landscape of cancer diagnosis, prognosis, and management. By offering a comprehensive overview of current developments and potential future directions, this review underscores the significance of CTCs in enhancing our understanding of cancer and in shaping personalized therapeutic strategies, particularly for patients with metastatic disease.
Reference116 articles.
1. Cancer. Circulating tumor cells;Plaks;Science,2013
2. A case of cancer in which cells similar to those in the tumours were seen in the blood after death;Ashworth;Med. J. Aust.,1869
3. Wang, W., Zheng, Z., and Lei, J. (2023). CTC, ctDNA, and Exosome in Thyroid Cancers: A Review. Int. J. Mol. Sci., 24.
4. Challenges in circulating tumour cell research;Pantel;Nat. Rev. Cancer,2014
5. Liquid biopsy: From concept to clinical application;Marchetti;Sci. Rep.,2023
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献