Affiliation:
1. Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212000, China
2. Hematological Disease Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, China
Abstract
The tumor EMT is a crucial event in tumor pathogenesis and progression. Previous research has established MBD3’s significant role in pancreatic cancer EMT. However, MBD3’s precise role in colon cancer remains unclear and warrants further investigation. Pan-cancer analysis revealed MBD3’s differential expression in various tumors and its significant association with tumor occurrence, growth, and progression. Moreover, analysis of single-cell sequencing and clinical data for colon cancer revealed MBD3 expression’s negative correlation with clinical indicators such as survival prognosis. Functional enrichment analysis confirmed the association between MBD3 and EMT in colon cancer. Pathological examinations, western blotting, and qRT-PCR in vitro and in vivo validated MBD3’s differential expression in colon cancer. Transwell, CCK-8, clone formation, and in vivo tumorigenesis experiments confirmed MBD3’s impact on migration, invasion, and proliferation. Our findings demonstrate MBD3 as a potential prognostic marker and therapeutic target for colon cancer.
Funder
National Natural Science Foundation of China
Jiangsu Provincial Key Research and Development Program
Natural Science Foundation of Jiangsu Province
Postgraduate Research and Practice Innovation Program of Jiangsu Province
Zhenjiang Key Research and Development Program
Cited by
2 articles.
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