Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)-Reference-Cited by-同舟云学术

Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)

Published:2024-02-27 Issue:5 Volume:16 Page:953
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Hendricks Linda A. J.¹²^ORCID,Verbeek Katja C. J.¹²^ORCID,Schuurs-Hoeijmakers Janneke H. M.¹,Mensenkamp Arjen R.¹²^ORCID,Brems Hilde³,de Putter Robin⁴^ORCID,Anastasiadou Violetta C.⁵,Villy Marie-Charlotte⁶,Jahn Arne⁷⁸⁹^ORCID,Steinke-Lange Verena¹⁰¹¹^ORCID,Baldassarri Margherita¹²¹³¹⁴^ORCID,Irmejs Arvids¹⁵¹⁶^ORCID,de Jong Mirjam M.¹⁷,Links Thera P.¹⁸,Leter Edward M.¹⁹,Bosch Daniëlle G. M.²⁰,Høberg-Vetti Hildegunn²¹^ORCID,Tveit Haavind Marianne²¹,Jørgensen Kjersti²²,Mæhle Lovise²²,Blatnik Ana²³,Brunet Joan²⁴^ORCID,Darder Esther²⁴,Tham Emma²⁵²⁶^ORCID,Hoogerbrugge Nicoline¹²^ORCID,Vos Janet R.¹²^ORCID

Affiliation:

1. Department of Human Genetics, Radboudumc Expert Center for PHTS, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

2. Radboud Institute for Medical Innovation, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

3. Department of Human Genetics, University of Leuven, 3000 Leuven, Belgium

4. Center for Medical Genetics, Ghent University Hospital, 9000 Ghent, Belgium

5. Karaiskakio Foundation, Nicosia Cyprus and Archbishop Makarios III Children’s Hospital, Nicosia 2012, Cyprus

6. Service de Génétique, Institut Curie, 75248 Paris, France

7. Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, Technische Universitat Dresden, 01062 Dresden, Germany

8. Hereditary Cancer Syndrome Center Dresden, 01307 Dresden, Germany

9. German Cancer Consortium (DKTK), 69120 Dresden, Germany

10. Medical Genetics Center, 80335 Munich, Germany

11. Arbeitsgruppe Erbliche Gastrointestinale Tumore, Medizinische Klinik und Poliklinik IV—Campus Innenstadt, Klinikum der Universität München, 81377 Munich, Germany

12. Medical Genetics, University of Siena, 53100 Siena, Italy

13. Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy

14. Genetica Medica, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy

15. Institute of Oncology, Riga Stradins University, 1007 Riga, Latvia

16. Breast Unit, Pauls Stradins Clinical University Hospital, 1002 Riga, Latvia

17. Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands

18. Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands

19. Department of Clinical Genetics, Maastricht University Medical Center, 6229 ER Maastricht, The Netherlands

20. Department of Clinical Genetics, Erasmus MC Rotterdam, 3015 GD Rotterdam, The Netherlands

21. Western Norway Familial Cancer Center, Department of Medical Genetics, Haukeland University Hospital, 5021 Bergen, Norway

22. Department of Medical Genetics, Oslo University Hospital, 0450 Oslo, Norway

23. Department of Clinical Cancer Genetics, Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia

24. Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL-IDIBGI, 08916 Barcelona, Spain

25. Department of Clinical Genetics, Karolinska University Hospital, 14186 Stockholm, Sweden

26. Department of Molecular Medicine and Surgery, Karolinska Institute, 17177 Stockholm, Sweden

Abstract

Females with PTEN Hamartoma Tumor Syndrome (PHTS) have breast cancer risks up to 76%. This study assessed associations between breast cancer and lifestyle in European female adult PHTS patients. Data were collected via patient questionnaires (July 2020–March 2023) and genetic diagnoses from medical files. Associations between lifestyle and breast cancer were calculated using logistic regression corrected for age. Index patients with breast cancer before PHTS diagnosis (breast cancer index) were excluded for ascertainment bias correction. In total, 125 patients were included who completed the questionnaire at a mean age of 44 years (SD = 13). This included 21 breast cancer indexes (17%) and 39 females who developed breast cancer at 43 years (SD = 9). Breast cancer patients performed about 1.1 times less often 0–1 times/week physical activity than ≥2 times (ORtotal-adj = 0.9 (95%CI 0.3–2.6); consumed daily about 1.2–1.8 times more often ≥1 than 0–1 glasses of alcohol (ORtotal-adj = 1.2 (95%CI 0.4–4.0); ORnon-breastcancer-index-adj = 1.8 (95%CI 0.4–6.9); were about 1.04–1.3 times more often smokers than non-smokers (ORtotal-adj = 1.04 (95%CI 0.4–2.8); ORnon-breastcancer-index-adj = 1.3 (95%CI 0.4–4.2)); and overweight or obesity (72%) was about 1.02–1.3 times less common (ORtotal-adj = 0.98 (95%CI 0.4–2.6); ORnon-breastcancer-index-adj = 0.8 (95%CI 0.3–2.7)). Similar associations between lifestyle and breast cancer are suggested for PHTS and the general population. Despite not being statistically significant, results are clinically relevant and suggest that awareness of the effects of lifestyle on patients’ breast cancer risk is important.

Funder

PTEN Research Foundation

Region Stockholm

Publisher

MDPI AG

Link

https://www.mdpi.com/2072-6694/16/5/953/pdf

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