Signaling by Type I Interferons in Immune Cells: Disease Consequences-Reference-Cited by-同舟云学术

Signaling by Type I Interferons in Immune Cells: Disease Consequences

Published:2024-04-22 Issue:8 Volume:16 Page:1600
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Zannikou Markella¹,Fish Eleanor N.²³,Platanias Leonidas C.¹⁴

Affiliation:

1. Robert H. Lurie Comprehensive Cancer Center, Division of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, 303 East Superior Ave., Chicago, IL 60611, USA

2. Toronto General Hospital Research Institute, University Health Network, 67 College Street, Toronto, ON M5G 2M1, Canada

3. Department of Immunology, University of Toronto, 1 King’s College Circle, Toronto, ON M5S 1A8, Canada

4. Department of Medicine, Jesse Brown Veterans Affairs Medical Center, 820 S. Damen Ave., Chicago, IL 60612, USA

Abstract

This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation.

Funder

NIH

Publisher

MDPI AG

Link

https://www.mdpi.com/2072-6694/16/8/1600/pdf

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