Pseudokinases, Tribbles Proteins and Cancer-Reference-Cited by-同舟云学术

Pseudokinases, Tribbles Proteins and Cancer

Published:2023-07-09 Issue:14 Volume:15 Page:3547
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Velasco Guillermo¹²^ORCID,Link Wolfgang³^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, 28040 Madrid, Spain

2. Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain

3. Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain

Abstract

The human kinome comprises 518 protein kinases, of which approximately 10% lack one or more of the conserved amino acids necessary for catalytic activity [...]

Funder

Spanish Ministry of Science, Innovation and Universities

Instituto de Salud Carlos III

European Regional Development Fund

European Commission

Breast Cancer Now (formerly Breast Cancer Campaign) foundation

Publisher

MDPI AG

Subject

Cancer Research,Oncology

Link

https://www.mdpi.com/2072-6694/15/14/3547/pdf

Reference13 articles.

1. Emerging roles of pseudokinases;Boudeau;Trends Cell Biol.,2006

2. Prospects for pharmacological targeting of pseudokinases;Kung;Nat. Rev. Drug Discov.,2019

3. Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease;Eyers;Trends Cell Biol.,2017

4. Mayoral-Varo, V., Jiménez, L., and Link, W. (2021). The Critical Role of TRIB2 in Cancer and Therapy Resistance. Cancers, 13.

5. Örd, T., Örd, D., Kaikkonen, M.U., and Örd, T. (2021). Pharmacological or trib3-mediated suppression of atf4 transcriptional activity promotes hepatoma cell resistance to proteasome inhibitor bortezomib. Cancers, 13.