Remdesivir Decreases Mortality in COVID-19 Patients with Active Malignancy

Author:

Jaroszewicz JerzyORCID,Kowalska JustynaORCID,Pawłowska MałgorzataORCID,Rogalska Magdalena,Zarębska-Michaluk DorotaORCID,Rorat MartaORCID,Lorenc BeataORCID,Czupryna Piotr,Sikorska Katarzyna,Piekarska AnnaORCID,Dworzańska Anna,Zaleska Izabela,Mazur Włodzimierz,Kozielewicz DorotaORCID,Kłos KrzysztofORCID,Podlasin ReginaORCID,Angielski Grzegorz,Oczko-Grzesik Barbara,Figlerowicz Magdalena,Szetela BartoszORCID,Bolewska Beata,Frańczak-Chmura Paulina,Flisiak RobertORCID,Tomasiewicz Krzysztof

Abstract

Data on the use of remdesivir, the first antiviral agent against SARS-CoV-2, are limited in oncologic patients. We aimed to analyze contributing factors for mortality in patients with malignancies in the real-world CSOVID-19 study. In total, 222 patients with active oncological disorders were selected from a nationwide COVID-19 study of 4890 subjects. The main endpoint of the current study was the 28-day in-hospital mortality. Approximately half of the patients were male, and the majority had multimorbidity (69.8%), with a median age of 70 years. Baseline SpO2 < 85% was observed in 25%. Overall, 59 (26.6%) patients died before day 28 of hospitalization: 29% due to hematological, and 20% due to other forms of cancers. The only factor increasing the odds of death in the multivariable model was eGFR < 60 mL/min/m2 (4.621, p = 0.02), whereas SpO2 decreased the odds of death at baseline (0.479 per 5%, p = 0.002) and the use of remdesivir (0.425, p = 0.03). This study shows that patients with COVID-19 and malignancy benefit from early remdesivir therapy, resulting in a decrease in early mortality by 80%. The prognosis was worsened by low glomerular filtration rate and low peripheral oxygen saturation at baseline underlying the role of kidney protection and early hospitalization.

Funder

Polish Association of Epidemiologists and Infectiologists

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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