Exploring miRNA Profiles in Colon Cancer: A Focus on miR101-3p, miR106a-5p, and miR326-Reference-Cited by-同舟云学术

Exploring miRNA Profiles in Colon Cancer: A Focus on miR101-3p, miR106a-5p, and miR326

Published:2024-06-20 Issue:12 Volume:16 Page:2285
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Tâlvan Constantin-Dan¹,Tâlvan Elena-Teodora¹,Mohor Călin Ilie¹,Budișan Liviuța²^ORCID,Grecu Valentin³^ORCID,Mihalache Manuela¹,Zănoagă Oana²,Chira Sergiu²,Berindan-Neagoe Ioana²^ORCID,Cristea Victor²,Mohor Cosmin Ioan¹

Affiliation:

1. Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, Romania

2. Research Center for Functional Genomic, Biomedicine and Translational Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania

3. Faculty of Engineering, “Lucian Blaga” University of Sibiu, 550025 Sibiu, Romania

Abstract

Early diagnosis and prognosis of cancer progression through biomarker profiling are crucial in managing colon cancer patients. Our research aimed to investigate the expression of miR-101-3p, miR-106a-5p, and miR-326 in tumor and adjacent healthy tissues of colon cancer patients and determine their potential diagnostic utility. This study included 40 patients divided into four groups according to the TNM staging classification. MiRNA expression was analyzed using qRT-PCR. The results showed that miR-101-3p, miR-106a-5p, and miR-326 are overexpressed in adjacent healthy tissues but decrease in advanced cancer stages. MiR-106a-5p and miR-326 are strongly correlated with colon cancer severity. These findings suggest that miRNA profiling could be useful for early diagnosis and prognosis in colon cancer management.

Publisher

MDPI AG

Link

https://www.mdpi.com/2072-6694/16/12/2285/pdf

Reference54 articles.

1. Competing Endogenous RNAs (ceRNAs) in Colorectal Cancer: A Review;Akhbari;Expert Rev. Mol. Med.,2022

2. Investigation of the Potential of miRNA Candidates as Non-Invasive Biomarkers for the Diagnosis and Follow-up of Colorectal Cancer;Karabulut;Pathol. Res. Pract.,2024

3. Current Understanding and Clinical Utility of miRNAs Regulation of Colon Cancer Stem Cells;Poeta;Semin. Cancer Biol.,2018

4. Serum-Based microRNA Signatures in Early Diagnosis and Prognosis Prediction of Colon Cancer;Radova;Carcinogenesis,2016

5. Bast, R.C., Hait, W.N., Kufe, D.W., Weichselbaum, R.R., Holland, J.F., Croce, C.M., Piccart-Gebart, M., Wang, H., Hong, W.K., and Pollock, R.E. (2022). Molecular Diagnostics in Cancer. Holland-Frei Cancer Medicine, Wiley.