Abstract
Autotaxin (ATX), the protein product of Ectonucleotide Pyrophosphatase Phosphodiesterase 2 (ENPP2), is a secreted lysophospholipase D (lysoPLD) responsible for the extracellular production of lysophosphatidic acid (LPA). ATX-LPA pathway signaling participates in several normal biological functions, but it has also been connected to cancer progression, metastasis and inflammatory processes. Significant research has established a role in breast cancer and it has been suggested as a therapeutic target and/or a clinically relevant biomarker. Recently, ENPP2 methylation was described, revealing a potential for clinical exploitation in liquid biopsy. The current review aims to gather the latest findings about aberrant signaling through ATX-LPA in breast cancer and discusses the role of ENPP2 expression and epigenetic modification, giving insights with translational value.
Funder
Hellenic Foundation for Research and Innovation
Reference120 articles.
1. Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein;J. Biol. Chem.,1992
2. Autotaxin (ATX): A multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties;Biochim. Biophys. Acta (BBA) Mol. Cell Biol. Lipids,2008
3. Zhang, X., Li, M., Yin, N., and Zhang, J. (2021). The Expression Regulation and Biological Function of Autotaxin. Cells, 10.
4. Regulation and biological activities of the autotaxin—LPA axis;Prog. Lipid Res.,2007
5. Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development;J. Mol. Cell Biol.,2006
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献