Pathological Features Associated with Lymph Node Disease in Patients with Appendiceal Neuroendocrine Tumors-Reference-Cited by-同舟云学术

Pathological Features Associated with Lymph Node Disease in Patients with Appendiceal Neuroendocrine Tumors

Published:2024-08-22 Issue:16 Volume:16 Page:2922
ISSN:2072-6694
Container-title:Cancers
language:en
Short-container-title:Cancers

Author:

Rodriguez Franco Salvador¹^ORCID,Ghaffar Sumaya Abdul¹^ORCID,Jin Ying²,Weiss Reed¹,Hamermesh Mona¹,Khomiak Andrii¹,Sugawara Toshitaka¹,Franklin Oskar¹,Leal Alexis D.³⁴,Lieu Christopher H.³⁴,Schulick Richard D.¹⁴,Del Chiaro Marco¹⁴,Ahrendt Steven¹,McCarter Martin D.¹⁴,Gleisner Ana L.¹^ORCID

Affiliation:

1. Division of Surgical Oncology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA

2. Department of Biostatistics and Informatics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA

3. Division of Medical Oncology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA

4. Cancer Center, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA

Abstract

This study aimed to evaluate the role of pathological features beyond tumor size in the risk of lymph node metastasis in appendiceal neuroendocrine tumors. Analyzing data from the national cancer database, we found that among 5353 cases, 18.8% had lymph node metastasis. Focusing on tumors smaller than 2 cm, a subject of considerable debate in treatment strategies, we identified lymphovascular invasion as one of the strongest predictors of lymph node disease. Interestingly, extension into the subserosa and beyond, a current factor in the staging system, was not a strong predictor. These findings suggest that careful interpretation of pathological features is needed when selecting therapeutic approaches using current staging systems.

Publisher

MDPI AG

Link

https://www.mdpi.com/2072-6694/16/16/2922/pdf

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