Impact of Region-of-Interest Size on the Diagnostic Performance of Shear Wave Elastography in Differentiating Thyroid Nodules

Author:

Cheng Kai-Lun12ORCID,Lai Pin-Hsien12,Su Chun-Lang34,Baek Jung Hwan5ORCID,Lee Hsiang-Lin26

Affiliation:

1. Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung 40201, Taiwan

2. School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan

3. Chung Jen Junior College of Nursing, Health Science and Management, Chiayi City 60077, Taiwan

4. Department of Rehabilitation, Tung Wah Hospital, Nantou City 55713, Taiwan

5. Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea

6. Department of Surgery, Chung Shan Medical University Hospital, Taichung 40201, Taiwan

Abstract

This study investigated the impact of different region-of-interest (ROI) sizes (Max, 1 mm, and 2 mm) on shear wave elastography (SWE) in differentiating between malignant and benign thyroid nodules. The study cohort comprised 129 thyroid nodules (50 malignant, 79 benign) and 78 normal subjects. Diagnostic efficacy was assessed through pairwise comparisons of area under the curve (AUC) values in receiver operating characteristic analysis by using DeLong’s test. Our results indicated significant differences in all SWE elasticity metrics between the groups, with malignant nodules exhibiting higher values than benign nodules (p < 0.05). Smaller ROIs (1 and 2 mm) were found to outperform the max ROI in terms of diagnostic accuracy, particularly for the Emax and Emin elasticity metrics. Emax(1mm) had the highest diagnostic accuracy, with an AUC of 0.883, sensitivity of 74.0%, and specificity of 86.1%. This study underscores the significant influence of ROI size selection on the diagnostic performance of SWE, offering valuable insights for future research and clinical applications in thyroid nodule assessment.

Publisher

MDPI AG

Subject

Cancer Research,Oncology

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