Affiliation:
1. Department of Pediatric Cardiology and Rheumatology, Medical University of Lodz, Sporna 36/50 Street, 91-738 Lodz, Poland
Abstract
Multisystem inflammatory syndrome in children (MIS-C) is a disease that made its mark in the early days of the COVID-19 pandemic due to the diverse course and symptoms affecting multiple body systems. It is a condition that develops in pediatric patients about 2–6 weeks after contact with a person infected with the SARS-CoV-2 virus. In many instances, MIS-C has caused multiple organ failure, with particularly severe complications involving the cardiovascular system and manifesting as hypotension, various cardiac arrhythmias, myocarditis or coronary artery lesions resembling those seen in Kawasaki disease. Currently, the incidence of MIS-C is about 1–3 per 1000 children, with a decreasing trend in recent years due to the introduction of immunization against the SARS-CoV-2 virus for children as young as 6 months. In our paper, we present the case of a patient with a severe course of MIS-C with numerous cardiovascular and neurological complications, in whom the symptoms of the disease were managed by administering biological treatment. We also present a review of the literature on the subject, which shows how many different facets this disease can have and that physicians still need to remain alert, as there are cases of severe MIS-C, especially in unvaccinated patients.
Funder
Medical University of Lodz
Reference44 articles.
1. (2024, June 12). WHO Scientific Statement. Multisystem Inflammatory Syndrome in Children and Adolescents with COVID. Available online: https://www.who.int/publications/i/item/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19.
2. La Torre, F., Taddio, A., Conti, C., and Cattalini, M. (2023). Multi-Inflammatory Syndrome in Children (MIS-C) in 2023: Is It Time to Forget about It?. Children, 10.
3. (2024, June 12). Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 Infection 2023 Case Definition|CDC. (n.d.), Available online: https://ndc.services.cdc.gov/case-definitions/multisystem-inflammatory-syndrome-in-children-mis-c-2023/a.
4. A New Definition for Multisystem Inflammatory Syndrome in Children;Son;Pediatrics,2023
5. Multisystem inflammatory syndrome in children: A systematic review;Ahmed;EClinicalMedicine,2020