High Fischer Ratio Oligopeptides of Gluten Alleviate Alcohol-Induced Liver Damage by Regulating Lipid Metabolism and Oxidative Stress in Rats

Author:

Zhao Penghui12,Hou Yinchen13ORCID,Chen Xinyang12,Zhang Mingyi12,Hu Zheyuan12,Chen Lishui1,Huang Jihong1245ORCID

Affiliation:

1. Food Laboratory of Zhong Yuan, Luohe 462300, China

2. School of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China

3. College of Food and Biological Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450044, China

4. Collaborative Innovation Center of Functional Food Green Manufacturing, Xuchang 461000, China

5. State Key Laboratory of Crop Stress Adaptation and Improvement, College of Agriculture, Henan University, Kaifeng 475004, China

Abstract

High Fischer ratio oligopeptides (HFOs) exhibit diverse biological activities, including anti-inflammatory and antioxidant properties. HFOs from gluten origin were prepared through fermentation and enzymatic hydrolysis and then characterized using free amino acid analysis and scanning electron microscopy (SEM). Following intervention, the levels of serum total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatic malondialdehyde (MDA) in the rats significantly decreased (p < 0.05). Simultaneously, there was an increasing trend in superoxide dismutase (SOD) levels, and glutathione (GSH) levels were significantly elevated (p < 0.05). The mRNA expression levels of alcohol metabolism-related genes (ADH4, ALDH2, and CYP2E1) exhibited a significant increase (p < 0.05). Histological examination revealed a reduction in liver damage. The findings indicate that high Fischer ratio oligopeptides, prepared through enzymatic and fermentation methods, significantly improve lipid levels, ameliorate lipid metabolism disorders, and mitigate oxidative stress, and exhibit a discernible alleviating effect on alcoholic liver injury in rats.

Funder

Major Science and Technology Projects for Public Welfare of Henan Province

Zhongyuan Scholar Workstation Funded Project

Zhongyuan Scholars of Henan Province in China

Central Government Guides the Local Science and Technology Development Special Fund

Henan Provincial Key Science and Technology Special Project

Key Research and Development Project of Henan Province

Publisher

MDPI AG

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