Author:
Hrabák P,Kalousová M,Krechler T,Zima T
Abstract
Pluripotent pancreatic stellate cells (PSCs) receive growing
interest in past decades. Two types of PSCs are recognized –
vitamin A accumulating quiescent PSCs and activated PSCs- the
main producents of extracellular matrix in pancreatic tissue. PSCs
plays important role in pathogenesis of pancreatic fibrosis in
pancreatic cancer and chronic pancreatitis. PSCs are intensively
studied as potential therapeutical target because of their
important role in developing desmoplastic stroma in pancreatic
cancer. There also exists evidence that PSC are involved in other
pathologies like type-2 diabetes mellitus. This article brings brief
characteristics of PSCs and recent advances in research of these
cells.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Cited by
8 articles.
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