Primary epithelioid inflammatory myofibroblastic sarcoma of the brain with EML4::ALK fusion mimicking intra-axial glioma: a case report and brief literature review

Abstract

An aggressive subtype of inflammatory myofibroblastic tumor, epithelioid inflammatory myofibroblastic sarcoma occurs primarily inside the abdominal cavity, followed by a pulmonary localization. Most harbor anaplastic lymphoma kinase (<i>ALK</i>) gene rearrangements, with <i>RANBP2</i> and <i>RRBP1</i> among the well-documented fusion partners. We report the second case of primary epithelioid inflammatory myofibroblastic sarcoma of the brain, with a well-known <i>EML4::ALK</i> fusion. The case is notable for its intra-axial presentation that clinico-radiologically mimicked glioma.