Contributions of Subregions of the Prefrontal Cortex to Working Memory: Evidence from Brain Lesions in Humans-Reference-Cited by-同舟云学术

Contributions of Subregions of the Prefrontal Cortex to Working Memory: Evidence from Brain Lesions in Humans

Published:2002-07-01 Issue:5 Volume:14 Page:673-686
ISSN:0898-929X
Container-title:Journal of Cognitive Neuroscience
language:en
Short-container-title:

Author:

Müller Notger G.¹²³,Machado Liana⁴³,Knight Robert T.²³

Affiliation:

1. University of Frankfurt

2. University of California at Berkeley and the Helen Wills Neuroscience Institute

3. Veterans Administration Medical Center, Martinez, CA

4. University of Wales

Abstract

Abstract We investigated working memory in patients with focal brain damage involving subregions of the prefrontal cortex (PFC). Lesions in the dorsal portion of lateral PFC or the ventromedial portion of orbital PFC did not impair performance in tasks that required maintenance and monitoring of object or spatial information. Larger lesions involving both ventral and dorsal parts of the lateral PFC impaired maintenance and monitoring of spatial and object information, with more severe deficits observed in the spatial tasks. The results support a distributed localization of function in lateral PFC during working memory.

Publisher

MIT Press - Journals

Subject

Cognitive Neuroscience

Link

http://direct.mit.edu/jocn/article-pdf/14/5/673/1934260/08989290260138582.pdf

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