The Treatment of Colorectal Cancer During Pregnancy: Cytotoxic Chemotherapy and Targeted Therapy Challenges

Author:

Rogers Jane E.1,Dasari Arvind2,Eng Cathy2

Affiliation:

1. a Pharmacy Clinical Programs, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

2. b Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Abstract

Abstract Cancer diagnosed during pregnancy has increased because of delayed child-bearing and the known occurrence of age-dependent malignancies. Cases of colorectal cancer (CRC) in pregnancy have recently been reported. With the expected rise in CRC diagnosed in young adults coupled with the current trend of delayed child-bearing, CRC during pregnancy is likely to increase. Treating pregnant women with CRC by using antineoplastics presents a dilemma because there are many unknowns to guide treatment decisions. We review the issues regarding the use of 10 CRC-approved agents in pregnancy.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

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