Cancer and Risk of COVID-19 Through a General Community Survey

Author:

Lee Karla A.1,Ma Wenjie2,Sikavi Daniel R.3,Drew David A.2,Nguyen Long H.2,Bowyer Ruth C. E.1,Cardoso M. Jorge4,Fall Tove56,Freidin Maxim B.1,Gomez Maria5,Graham Mark4,Guo Chuan-Guo2,Joshi Amit D.2,Kwon Sohee2,Lo Chun-Han2,Lochlainn Mary Ni1,Menni Cristina1,Murray Benjamin4,Mehta Raaj2,Song Mingyang2,Sudre Carole H.4,Bataille Veronique1,Varsavsky Thomas4,Visconti Alessia1,Franks Paul W.5,Wolf Jonathan7,Steves Claire J.1,Ourselin Sebastien4,Spector Tim D.1,Chan Andrew T.289,

Affiliation:

1. Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom

2. Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

3. Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

4. School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom

5. Department of Clinical Sciences, Lund University, Malmö, Sweden

6. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Sweden

7. Zoe Global Limited, London, United Kingdom

8. Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health. Boston, Massachusetts, USA

9. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

Abstract

Abstract Individuals with cancer may be at high risk for coronavirus disease 2019 (COVID-19) and adverse outcomes. However, evidence from large population-based studies examining whether cancer and cancer-related therapy exacerbates the risk of COVID-19 infection is still limited. Data were collected from the COVID Symptom Study smartphone application since March 29 through May 8, 2020. Among 23,266 participants with cancer and 1,784,293 without cancer, we documented 10,404 reports of a positive COVID-19 test. Compared with participants without cancer, those living with cancer had a 60% increased risk of a positive COVID-19 test. Among patients with cancer, current treatment with chemotherapy or immunotherapy was associated with a 2.2-fold increased risk of a positive test. The association between cancer and COVID-19 infection was stronger among participants >65 years and males. Future studies are needed to identify subgroups by tumor types and treatment regimens who are particularly at risk for COVID-19 infection and adverse outcomes.

Funder

Medical Research Council

Swedish Foundation for Strategic Research

The Alzheimers Society

Wellcome Trust

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Reference8 articles.

1. Rapid implementation of mobile technology for real-time epidemiology of COVID-19;Drew;Science,2020

2. Real-time tracking of self-reported symptoms to predict potential COVID-19;Menni;Nat Med,2020

3. Patients with cancer appear more vulnerable to SARS-CoV-2: A multicenter study during the COVID-19 outbreak;Dai;Cancer Discov,2020

4. Cancer patients in SARS-CoV-2 infection: A nationwide analysis in China;Liang;Lancet Oncol,2020

5. Do patients with cancer have a poorer prognosis of COVID-19? An experience in New York City;Miyashita;Ann Oncol,2020

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