Proautophagic Drugs: A Novel Means to Combat Apoptosis-Resistant Cancers, with a Special Emphasis on Glioblastomas-Reference-Cited by-同舟云学术

Proautophagic Drugs: A Novel Means to Combat Apoptosis-Resistant Cancers, with a Special Emphasis on Glioblastomas

Published:2007-12-01 Issue:12 Volume:12 Page:1395-1403
ISSN:1083-7159
Container-title:The Oncologist
language:en
Short-container-title:

Author:

Lefranc Florence¹²,Facchini Vincenzo³,Kiss Robert²

Affiliation:

1. a Department of Neurosurgery, Erasme University Hospital, Brussels, Belgium

2. b Laboratory of Toxicology, Institute of Pharmacy, Université Libre de Bruxelles, Brussels, Belgium

3. c Unibioscreen SA, Brussels, Belgium

Abstract

Learning Objectives After completing this course, the reader will be able to: Describe the pathways involved in the natural resistance of cancer cells to cytotoxic insults including radio-/chemotherapy.Explain autophagic cell death as a potent alternative tumor-suppressing mechanism.Identify the common targets in apoptosis and autophagy resistance pathways and the surrogate markers that could be used in clinical practice for proautophagic therapy.Discuss the rationale for incorporating endoplasmic reticulum stress inhibitors as adjuvant chemotherapies against apoptosis-resistant cancers. Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1634/theoncologist.12-12-1395

Reference84 articles.

1. Apoptotic pathways and therapy resistance in human malignancies;Viktorsson;Adv Cancer Res,2005

2. Chemotherapeutic approaches for targeting cell death pathways;Ricci;The Oncologist,2006

3. Pathways of apoptotic and non-apoptotic death in tumour cells;Okada;Nat Rev Cancer,2004

4. Promoting apoptosis as a strategy for cancer drug discovery;Fesik;Nat Rev Cancer,2005

5. Therapy: Inhibiting the inhibitors;McCarthy;Nat Rev Cancer,2007

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