Study of Non-HDL Cholesterol Level in Adult Patients Attending Rural Tertiary Care Hospital Chengalpattu District

Abstract

INTRODUCTION: Disease of the coronary artery is pivotal and accounts to high incidence of morbidity and mortality world over. Research have shown its impact on the economy which is a concern in the third world countries like India. The main cause of coronary artery disease is development of atherosclerosis, a cascade of chronic inflammation of the arteries. Abnormal concentration of non-HDL-C have evidenced in predisposing to CAD. The lipoproteins subtypes excluding HDL, which includes LDL, IDL, VLDL and chylomicrons are described as non-HDL-C. With this background our study aimed to analyse the concentration of non-HDL-C among adult patients attending a rural tertiary care hospital Chengalpattu district. METHODOLOGY: The research was conducted to analyse the concentration of non-HDL-C in adult patients attending tertiary care hospital, rural area, Chengalpattu district. The cross-sectional study was conducted in the central clinical laboratory at a rural tertiary care hospital, Chengalpattu district, six months data was collected from December 2021 to May 2022. Data from 336 patients were evaluated. The formula for calculating non-HDL-C concentration is: non-HDL cholesterol concentration(mg/dl) = Total cholesterol concentration – HDL cholesterol concentration. The biological reference range of non-HDL-C is ≤ 130 mg/ dl. RESULT: The Study found an association between diabetes and levels of Non-HDL-C (χ2 = 6.571, P = 0.010). Participants with hypertension had higher levels of Non-HDL-C (χ2 = 20.515, P = 0.0001). CONCLUSION: The research concluded high association of non-HDL cholesterol concentration with disease of the cardiovascular system. It was also found that participants with Diabetes mellitus along with Hypertension had higher concentration of non-HDL-C. Recent guidelines have stressed the importance of stringent target in lipid levels in high risk population. The analysis of non-HDL-C level is easy, convenient and economical, it should be prescribed for all high-risk patients especially in diabetes and hypertensives. Physicians should add non-HDL-Cas a routine parameter in lipid profile.