Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis
Author:
Affiliation:
1. ULB Center for Diabetes Research, Université Libre de Bruxelles, 1070 Brussels, Belgium
2. Department of Endocrinology and Metabolism, University of Pisa, 56126 Pisa, Italy
3. Division of Endocrinology, Erasmus Hospital, 1070 Brussels, Belgium
Publisher
The Endocrine Society
Subject
Endocrinology
Link
http://academic.oup.com/endo/article-pdf/158/6/1659/17643281/en.2016-1773.pdf
Reference59 articles.
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2. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation;Sako;Endocrinology,1990
3. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle;Zhou;J Clin Invest,1994
4. Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation;Cnop;Diabetes,2001
5. Initiation and execution of lipotoxic ER stress in pancreatic β-cells;Cunha;J Cell Sci,2008
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