A Pegylated Growth Hormone Receptor Antagonist, Pegvisomant, Does Not Enter the Brain in Humans-Reference-Cited by-同舟云学术

A Pegylated Growth Hormone Receptor Antagonist, Pegvisomant, Does Not Enter the Brain in Humans

Published:2010-08-01 Issue:8 Volume:95 Page:3844-3847
ISSN:0021-972X
Container-title:The Journal of Clinical Endocrinology & Metabolism
language:en
Short-container-title:

Author:

Veldhuis Johannes D.¹,Bidlingmaier Martin²,Bailey Joy¹,Erickson Dana¹,Sandroni Paola³

Affiliation:

1. Endocrine Research Unit (J.D.V., J.B., D.E.), Mayo School of Graduate Medical Education, Clinical Translational Research Center, Mayo Clinic, Rochester, Minnesota 55905;

2. Medizinische Klinik (M.B.), 80336 Munich, Germany

3. Department of Neurology (P.S.), Mayo School of Graduate Medical Education, Clinical Translational Research Center, Mayo Clinic, Rochester, Minnesota 55905;

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Link

http://academic.oup.com/jcem/article-pdf/95/8/3844/9068433/jcem3844.pdf

Reference21 articles.

1. Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition.;Veldhuis;Endocr Rev,2006

2. Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance.;Colao;Eur J Endocrinol,2006

3. Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy.;Yin;Clin Cancer Res,2007

4. The impact of pegvisomant treatment on substrate metabolism and insulin sensitivity in patients with acromegaly.;Lindberg-Larsen;J Clin Endocrinol Metab,2007

5. Lowering total plasma insulin-like growth factor I concentrations by way of a novel, potent, and selective growth hormone (GH) receptor antagonist, pegvisomant (B2036-peg), augments the amplitude of GH secretory bursts and elevates basal/nonpulsatile GH release in healthy women and men.;Veldhuis;J Clin Endocrinol Metab,2001

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