Author:
Yakar Shoshana,Nunez Nomeli P.,Pennisi Patricia,Brodt Pnina,Sun Hui,Fallavollita Lucia,Zhao Hong,Scavo Louis,Novosyadlyy Ruslan,Kurshan Naamit,Stannard Bethel,East-Palmer Joyce,Smith Nicole C. P.,Perkins Susan N.,Fuchs-Young Robin,Barrett J. Carl,Hursting Stephen D.,LeRoith Derek
Abstract
Obesity increases the risk of many cancers in both males and females. This study describes a link between obesity, obesity-associated metabolic alterations, and the risk of developing cancer in male and female mice. The goal of this study was to evaluate the relationship between gender and obesity and to determine the role of estrogen status in obese females and its effect on tumor growth. We examined the susceptibility of C57BL/6 mice to diet-induced obesity, insulin resistance/glucose intolerance, and tumors. Mice were injected sc with one of two tumorigenic cell lines, Lewis lung carcinoma, or mouse colon 38-adenocarcinoma. Results show that tumor growth rate was increased in obese mice vs. control mice irrespective of the tumor cell type. To investigate the effect of estrogen status on tumor development in obese females, we compared metabolic parameters and tumor growth in ovariectomized (ovx) and intact obese female mice. Obese ovx female mice developed insulin resistance and glucose intolerance similar to that observed in obese males. Our results demonstrate that body adiposity increased in ovx females irrespective of the diet administered and that tumor growth correlated positively with body adiposity. Overall, these data point to more rapid tumor growth in obese mice and suggest that endogenous sex steroids, together with diet, affect adiposity, insulin sensitivity, and tumor growth in female mice.
Reference63 articles.
1. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002;Hedley;JAMA,2004
2. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults;Calle;N Engl J Med,2003
3. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer;Ames;Mutat Res,2001
4. Diet and risk of colorectal cancer in a cohort of Finnish men;Pietinen;Cancer Causes Control,1999
5. Dietary fat and carcinogenesis;Woutersen;Mutat Res,1999
Cited by
127 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献