Insulin-Degrading Enzyme Does Not Require Peroxisomal Localization for Insulin Degradation*

Author:

Chesneau Valérie1,Perlman Rachel K.21,Li Wenlu3,Keller Gilbert-André3,Rosner Marsha Rich1

Affiliation:

1. Ben May Institute for Cancer Research (V.C., R.K.P., M.R.R.), The University of Chicago, Chicago, Illinois 60637

2. Columbia University College of Physicians and Surgeons (R.K.P.), New York, New York 10032

3. Department of Pharmacology (W.L., G.-A.K.), Genetech, Inc., San Francisco, California 94080

Publisher

The Endocrine Society

Subject

Endocrinology

Reference53 articles.

1. Signal transmission by the insulin-like growth factors.;Czech;Cell,1989

2. After insulin binds.;Rosen;Science,1987

3. Insulin degradation: mechanisms, products, and significance.;Duckworth;Endocr Rev,1988

4. Retroendocytosis of insulin in rat adipocytes.;Levy;Endocrinology,1986

5. Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding.;Gehm;J Biol Chem,1993

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