A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update-Reference-Cited by-同舟云学术

A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update

Published:2019-10-13 Issue:4 Volume:105 Page:e937-e946
ISSN:0021-972X
Container-title:The Journal of Clinical Endocrinology & Metabolism
language:en
Short-container-title:

Author:

Giustina Andrea¹,Barkan Ariel²,Beckers Albert³,Biermasz Nienke⁴,Biller Beverly M K⁵,Boguszewski Cesar⁶,Bolanowski Marek⁷,Bonert Vivien⁸,Bronstein Marcello D⁹,Casanueva Felipe F¹⁰,Clemmons David¹¹,Colao Annamaria¹²,Ferone Diego¹³,Fleseriu Maria¹⁴,Frara Stefano¹,Gadelha Monica R¹⁵,Ghigo Ezio¹⁶,Gurnell Mark¹⁷,Heaney Anthony P¹⁸,Ho Ken¹⁹,Ioachimescu Adriana²⁰,Katznelson Laurence²¹,Kelestimur Fahrettin²²,Kopchick John²³,Krsek Michal²⁴,Lamberts Steven²⁵,Losa Marco²⁶,Luger Anton²⁷,Maffei Pietro²⁸,Marazuela Monica²⁹,Mazziotti Gherardo³⁰,Mercado Moises³¹,Mortini Pietro²⁶,Neggers Sebastian³²,Pereira Alberto M⁴^ORCID,Petersenn Stephan³³,Puig-Domingo Manel³⁴,Salvatori Roberto³⁵,Shimon Ilan³⁶,Strasburger Christian³⁷,Tsagarakis Stylianos³⁸,van der Lely A J³²,Wass John³⁹,Zatelli Maria Chiara⁴⁰,Melmed Shlomo⁸^ORCID

Affiliation:

1. Division of Endocrinology and Metabolism, San Raffaele University Hospital, Milan, Italy

2. Division of Endocrinology, University of Michigan Health System, Ann Arbor, Michigan

3. Department of Endocrinology, University of Liège, Liège, Belgium

4. Division of Endocrinology and Center for Endocrine Tumors, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands

5. Neuroendocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

6. SEMPR, Endocrine Division, Department of Internal Medicine, Federal University of Parana, Curitiba, Brazil

7. Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland

8. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California

9. Division of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo, Sao Paulo, Brazil

10. Division of Endocrinology, Santiago de Compostela University and Ciber OBN, Santiago de Compostela, Spain

11. Department of Medicine, University of North Carolina, Chapel Hill, North Carolina

12. Division of Endocrinologia, Universita’ Federico II di Napoli, Naples, Italy

13. Endocrinology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy

14. Departments of Medicine and Neurological Surgery, Pituitary Center, Oregon Health & Science University, Portland, Oregon

15. Neuroendocrinology Research Center/Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

16. Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy

17. University of Cambridge & Addenbrooke’s Hospital, Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom

18. Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California

19. The Garvan Institute of Medical Research and St. Vincent’s Hospital, Sydney, Australia

20. Department of Medicine, Division of Endocrinology, Metabolism and Lipids, and Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia

21. Departments of Medicine and Neurosurgery, Stanford University School of Medicine, Stanford, California

22. Yeditepe University, Faculty of Medicine, Istanbul, Turkey

23. Edison Biotechnology Institute and Department of Biomedical Sciences, Ohio University, Athens, Ohio

24. 2nd Department of Medicine, 3rd Faculty of Medicine of the Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic

25. Erasmus Medical Center, Rotterdam, The Netherlands

26. Department of Neurosurgery, San Raffaele University Health Institute Milan, Milan, Italy

27. Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria

28. Department of Medicine, Padua University Hospital, Padua, Italy

29. Department of Medicine, CIBERER, Universidad Autónoma de Madrid, Madrid, Spain

30. Endocrinology Unit, Humanitas University and Humanitas Clinical and Research Center, Rozzano, Milan, Italy

31. Division of Medicine, National Autonomous University of Mexico, Experimental Endocrinology Unit, Centro Médico Nacional, Siglo XXI, IMSS, Mexico City, Mexico

32. Pituitary Center Rotterdam, Endocrinology Section, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

33. ENDOC Center for Endocrine Tumors, Hamburg, Germany

34. Endocrinology Service, CIBER and CIBERES Germans Trias i Pujol Research Institute and Hospital, Autonomous University of Barcelona, Badalona, Spain

35. Division of Endocrinology, Diabetes, and Metabolism and Pituitary Center, Johns Hopkins School of Medicine, Baltimore, Maryland

36. Endocrine Institute, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel

37. Department of Medicine for Endocrinology, Diabetes and Nutritional Medicine, Charité Universitätsmedizin, Berlin, Germany

38. Department of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens, Greece

39. Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom

40. Section of Endocrinology & Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy

Abstract

Abstract Objective The aim of the Acromegaly Consensus Group was to revise and update the consensus on diagnosis and treatment of acromegaly comorbidities last published in 2013. Participants The Consensus Group, convened by 11 Steering Committee members, consisted of 45 experts in the medical and surgical management of acromegaly. The authors received no corporate funding or remuneration. Evidence This evidence-based consensus was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence following critical discussion of the current literature on the diagnosis and treatment of acromegaly comorbidities. Consensus Process Acromegaly Consensus Group participants conducted comprehensive literature searches for English-language papers on selected topics, reviewed brief presentations on each topic, and discussed current practice and recommendations in breakout groups. Consensus recommendations were developed based on all presentations and discussions. Members of the Scientific Committee graded the quality of the supporting evidence and the consensus recommendations using the GRADE system. Conclusions Evidence-based approach consensus recommendations address important clinical issues regarding multidisciplinary management of acromegaly-related cardiovascular, endocrine, metabolic, and oncologic comorbidities, sleep apnea, and bone and joint disorders and their sequelae, as well as their effects on quality of life and mortality.

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Link

http://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgz096/30140466/dgz096.pdf

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