ERβ in Granulosa Cell Tumors and Its Clinical Potential-Reference-Cited by-同舟云学术

ERβ in Granulosa Cell Tumors and Its Clinical Potential

Published:2023-04-17 Issue:6 Volume:164 Page:
ISSN:1945-7170
Container-title:Endocrinology
language:en
Short-container-title:

Author:

Birgersson Madeleine¹²,Indukuri Rajitha¹,Antonson Per²,Nalvarte Ivan²,Archer Amena¹²,Williams Cecilia¹²^ORCID

Affiliation:

1. Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology , 171 21 Solna , Sweden

2. Department of Biosciences and Nutrition, Karolinska Institutet , 141 83 Huddinge , Sweden

Abstract

Abstract Granulosa cell tumors (GCTs) are rare ovarian tumors comprising an adult and a juvenile subtype. They have a generally good prognosis, but the survival rate drastically declines in patients with late-stage or recurring tumors. Due to the rarity of GCTs, the tumor type is largely understudied and lacks a specific treatment strategy. Estrogen receptor beta (ERβ/ESR2) has been found to be highly expressed in GCTs, which could be of therapeutic importance since it can be targeted with small molecules. However, its role in GCTs is not known. In this review, we summarize the current knowledge about the action of ERβ in the ovary and discuss its prospective role in GCTs.

Funder

The Swedish Cancers Society/Cancerfonden

Swedish Research Council/Vetenskapsrådet

Karolinska Institutet KID

Karolinska Institutet foundations

Publisher

The Endocrine Society

Subject

Endocrinology

Link

https://academic.oup.com/endo/advance-article-pdf/doi/10.1210/endocr/bqad063/50035265/bqad063.pdf

Reference115 articles.