Affiliation:
1. Department of Medicine, Division of Endocrinology, University of Cincinnati, Cincinnati, Ohio 45267-0547
Abstract
Abstract
Progressive insulin secretory defects, due to either functional abnormalities of the pancreatic β-cells or a reduction in β-cell mass, are the cornerstone of type 2 diabetes. Incretin-based drugs hold the potential to improve glucose tolerance by immediate favorable effect on β-cell physiology as well as by expanding or at least maintaining β-cell mass, which may delay the progression of the disease. Long-term studies in humans are needed to elaborate on these effects.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Cited by
93 articles.
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