1. Department of Medicine (T.H., J.M., K.K., M.H., S.L., F.U.), Division of Endocrinology, Metabolism, and Lipid Research, St Louis, Missouri 63110;
2. Cardiovascular-Metabolics Research Laboratories (T.H.), Daiichi Sankyo Co, Ltd, Tokyo 103-8426, Japan
3. Department of Pathology and Immunology (F.U.), Washington University School of Medicine, St Louis, Missouri 63110;