Bidirectional GPR119 Agonism Requires Peptide YY and Glucose for Activity in Mouse and Human Colon Mucosa-Reference-Cited by-同舟云学术

Bidirectional GPR119 Agonism Requires Peptide YY and Glucose for Activity in Mouse and Human Colon Mucosa

Published:2018-02-19 Issue:4 Volume:159 Page:1704-1717
ISSN:1945-7170
Container-title:Endocrinology
language:en
Short-container-title:

Author:

Tough Iain R¹,Forbes Sarah¹,Herzog Herbert²,Jones Robert M³,Schwartz Thue W⁴,Cox Helen M¹

Affiliation:

1. King’s College London, Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom

2. Garvan Institute of Medical Research, Darlinghurst New South Wales, Sydney, Australia

3. Department of Medicinal Chemistry, Arena Pharmaceuticals, San Diego, California

4. Section for Metabolic Receptology and Enteroendocrinology, Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

Publisher

The Endocrine Society

Subject

Endocrinology

Link

http://academic.oup.com/endo/article-pdf/159/4/1704/25085657/en.2017-03172.pdf

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3. A role for intestinal endocrine cell-expressed GPR119 in glycemic control by enhancing GLP-1 and GIP release;Chu;Endocrinology,2008

4. Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells;Parker;Diabetologia,2009

5. GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function;Odori;Metabolism,2013

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