Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D

Author:

Erben Reinhold G.1,Soegiarto Desi W.2,Weber Karin1,Zeitz Ute1,Lieberherr Michèle3,Gniadecki Robert4,Möller Gabriele5,Adamski Jerzy5,Balling Rudi2

Affiliation:

1. Institute of Animal Physiology, Ludwig Maximilians University (R.G.E., K.W., U.Z.), 80539 Munich, Germany

2. Institute of Mammalian Genetics, GSF National Research Center for Environment and Health (D.W.S., R.B.), 85764 Neuherberg, Germany

3. National Center for Scientific Research, UPR 1524, National Institute of Agricultural Research (M.L.), 78 350 Jouy-en-Josas, France

4. Department of Dermatology D92, Bispebjerg Hospital (R.G.), 2400 Copenhagen NV, Denmark

5. Institute of Experimental Genetics, GSF National Research Center for Environment and Health (G.M., J.A.), 85764 Neuherberg, Germany

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference55 articles.

1. Hormones and disorders of mineral metabolism;Bringhurst,1998

2. The steroid and thyroid hormone receptor superfamily.;Evans;Science,1988

3. The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets.;Malloy;Endocr Rev,1999

4. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning.;Yoshizawa;Nat Genet,1997

5. Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia.;Li;Proc Natl Acad Sci USA,1997

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