1. Department of Regulation Biology, Faculty of Science, Saitama University (M.M., K.F., K.I.), 255 Shimo-ohkubo, Urawa 338-0825, Japan
2. Department of Discovery Research Laboratories I, Pharmaceutical Discovery Research Division, Takeda Chemical Industries Co., Ltd. (H.M., J.N., C.K., M.F.), 10 Wadai, Tsukuba, Ibaraki 300-4293, Japan