Insulin-Like Growth Factor (IGF) Binding Protein-3 Inhibits Type 1 IGF Receptor Activation Independently of Its IGF Binding Affinity**This work was supported by the Institut National de la Santé et de la Recherche Médicale and the University of Paris VI.
Author:
Affiliation:
1. Institut National de la Santé et de la Recherche Médicale, Unité 515, Croissance, Différenciation et Processus tumoraux, Hôpital Saint-Antoine, Paris, France
Publisher
The Endocrine Society
Subject
Endocrinology
Link
http://academic.oup.com/endo/article-pdf/142/1/108/10362205/endo0108.pdf
Reference13 articles.
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3. Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells.;Oh;J Biol Chem,1993
4. The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene.;Valentinis;Mol Endocrinol,1995
5. Insulin-like growth factor-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-β1 on programmed cell death through a p53- and IGF-independent mechanism.;Rajah;J Biol Chem,1997
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