Insulin-Like Growth Factor (IGF) Binding Protein-3 Inhibits Type 1 IGF Receptor Activation Independently of Its IGF Binding Affinity**This work was supported by the Institut National de la Santé et de la Recherche Médicale and the University of Paris VI.

Author:

Ricort Jean-Marc1,Binoux Michel1

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale, Unité 515, Croissance, Différenciation et Processus tumoraux, Hôpital Saint-Antoine, Paris, France

Publisher

The Endocrine Society

Subject

Endocrinology

Reference13 articles.

1. Molecular and cellular aspects of the insulin-like growth factor I receptor.;LeRoith;Endocr Rev,1995

2. IGF binding proteins as modulators of IGF action.;Martin,1999

3. Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells.;Oh;J Biol Chem,1993

4. The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene.;Valentinis;Mol Endocrinol,1995

5. Insulin-like growth factor-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-β1 on programmed cell death through a p53- and IGF-independent mechanism.;Rajah;J Biol Chem,1997

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