Association of glutathione-S-transferase gene polymorphisms with various disease (review of foreign studies)

Abstract

Introduction. This review is devoted to the association of GSTM1, GSTT1, GSTP1 gene polymorphisms with various diseases in foreign literature sources. Material and methods. For this article, we used data published in foreign literature over the past 11 years. medline was extensively searched for eligible studies using the Pubmed search engine, and 30 studies were eventually selected for inclusion in this review. Results. This review showed that researchers all over the world have repeatedly tried to evaluate the relationship between GST polymorphisms and various diseases, but in some cases received conflicting results. At the same time, many studies have found an association of pathologies with both single GST gene polymorphisms and combined polymorphic variants, which indicates a complex effect of antioxidant system genes. Limitation of the study. The limitation of this review is the lack of domestic literary sources. Conclusion. Further research of functional polymorphisms of the GST family genes are needed to develop effective systems for the diagnosis, prevention, and treatment of diseases.