STUDY OF THE ANTIMICROBIAL ACTION OF «SANATION +» FOR THE PREVENTION AND TREATMENT OF ACUTE RESPIRATORY DISEASES

Abstract

State of the problem. Given the extreme threat of the Covid-19 pandemic in Ukraine to combat it, it is now important to develop and use effective antimicrobials, including disinfectants to disrupt the transmission mechanisms of the pathogen. Promising for use are the means obtained by electrolysis. The aim of the work. The study was to determine the specific activity and safety of «Sanation+», the effectiveness of disinfection of the mucous membranes of the upper respiratory tract of volunteers and evaluate the effectiveness of the tool for the treatment of patients with Сovid-19 and for the prevention of respiratory diseases. Materials and methods. The study used a medical device «Sanation+», which contains hydrochloric acid, highly active oxygen compounds of chlorine, free radicals of chlorine and oxygen, NaCl (mass concentration of active chlorine – 0.035%). The antimicrobial action of the product according to the Order of the Ministry of Health of Ukraine N 2024, dated September 3, 2020. To study the effectiveness of decontamination of the upper respiratory tract of volunteers with the «Sanation+» used devices for the formation of aerosols: – nebulizer «Nano Mist Sprayer» (China), which sprays the drug with a volume of 1.25 - 1.45 cm3 for 60 seconds. The distance from the spray to the mucous membranes was 5 - 10 cm; – compressor inhaler, model CN-123 (Japan). Results. It was found that the tool «Sanation+» showed high virilicidel, bactericidal and yeastic activity under exposure for 30 and 60 sec. for Escherichia coli K12 NCTC 10538 lg R > 5.42, for Pseudomonas aeruginosa lg R > 5.37; for Staphylococcus aureus lg R > 5.34; for Candida albicans lg R > 4.31. Remediation + when used undiluted and exposed for 30 sec is an effective tool for disinfection from macro- and microviruses, as evidenced by the high logarithms of the reduction of bacteriophages: T2 – > 5.08 lg, MS2 – > 5.12 lg, indicating the virucidal action of the tool against enveloped and non-enveloped viruses. As a result of the application of «Sanation+» through the nebulizer «Nano Mist Sprayer» there was a significant reduction in the number of microorganisms on the mucosal surface of nasal volunteers: after 5 min the drug decreased by 4.22 lg, on the throat mucosa – by 4.14 lg. The use of the drug through an inhaler helped to reduce the number of microorganisms on the surface of the mucous membranes of both the nose and throat. The most effective duration of action is 5 min (reduction factor: for the nasal mucosa RF = 4.23, for the throat mucosa RF = 4.78). Conclusions. High efficiency of means for rehabilitation of respiratory tracts «Sanation+», for application in complex therapy at treatment of a coronavirus disease at 55 patients is established. The use of «Sanation+» for the prevention of Covid-19 among health care workers in medical institutions of the disease was not detected. Key words: remedy «Sanation+», bactericidal, virucidal, volunteers, patients, Сovid-19.