Sexual and gender minorities (SGM) constitute vulnerable groups in many countries. Thus, they might be affected to a different extent than heterosexual and cisgender individuals by the Coronavirus pandemic. The aim of this systematic review is to summarize the current state of international research on the effects of the Coronavirus pandemic on SGM individuals. Following the PRISMA protocol, we synthesized 35 publications including different article formats. Key findings yield that SGM individuals overall suffer to a larger extent from combinations of both minority- and pandemic-specific stressors. Some evidence was contradicting across studies, for example changes in the extent of risk behavior, and minority stress experiences during the pandemic. Although our review distinctively spots on the impact of the pandemic on SGM individuals’ lives, its pathways still remain to be better understood. Moreover, future research should also examine the yet unforeseeable long-term consequences of the pandemic for SGM populations.