The spread of misinformation online is a global problem that requires global solutions. To that end, we conducted an experiment in 16 countries across 6 continents (N = 33,480) to investigate predictors of susceptibility to misinformation and interventions to combat misinformation. In every country, participants with a more analytic cognitive style and stronger accuracy-related motivations were better at discerning truth from falsehood; valuing democracy was also associated with greater truth discernment whereas political conservatism was negatively associated with truth discernment in most countries. Subtly prompting people to think about accuracy was broadly effective at improving the veracity of news that people were willing to share, as were minimal digital literacy tips. Finally, crowdsourced accuracy evaluation was able to differentiate true from false headlines with high accuracy in all countries. The consistent patterns we observe suggest that the psychological factors underlying the misinformation challenge are similar across the globe, and that similar solutions may be broadly effective.