Purpose: This study assesses distress/anxiety and predictors of distress/anxiety associated with quarantine due to COVID-19 exposure among the first quarantined community in the US, and to identify potential areas of intervention.Design: An anonymous survey was distributed via community organization distribution lists to approximately 1250 constituents under a quarantine directive.Setting: Members of the first community in the NYC area under quarantine orders due to the 2020 COVID-19 outbreak.Intervention: We sought to uncover the most salient predictors of distress/anxiety in order to recommend specific areas for effective intervention to reduce distressMeasures: We measured distress by using the Subjective Units of Distress Scale and anxiety with the Beck Anxiety Inventory. A variety of psychosocial predictors relevant to the current crisis were explored. Results: 303 individuals responded within 48 hours of survey distribution. Mean levels of distress in the sample were heightened and sustained, with 69% reporting moderate to severe distress. Modifiable behavioral factors, specifically with regard to media exposure and sleep quality, predicted the largest percentage of variance in the sample (41.9%, F (3, 264) = 40.7, R = 0.65, p < .001).Conclusion: Distress levels were markedly elevated among those in quarantine. The highest percentage of distress/anxiety variance was accounted for by modifiable factors amenable to behavioral and psychological interventions, including promoting healthy sleep and curtailing media use. Access to professional mental health care as well as behavioral interventions should be prioritized.