Affiliation:
1. Key Laboratory of Geriatric Nutrition and Health (Beijing Technology and Business University) Ministry of Education Beijing China
2. Key Laboratory of Brewing Microbiome and Enzymatic Molecular Engineering China General Chamber of Commerce Beijing China
3. School of Food and Health Beijing Technology and Business University Beijing China
4. Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology and Business University Beijing China
5. Environmental Impact and Sustainability Division CSIR‐National Environmental Engineering Research Institute (CSIR‐NEERI) Nagpur Maharashtra India
6. Beijing Association for Science and Technology‐Food Nutrition and Safety Professional Think Tank Base Beijing China
Abstract
AbstractImmobilized lipase is a powerful biocatalytic system with numerous applications in industries, particularly in the energy, pharmaceutical, cosmetic, and food industries. Reusability, simple recovery, and high chemical and thermal stability make it an attractive alternative to traditional chemical catalysts in industrial applications. Novel methods and support materials for immobilizing lipases have recently attracted much attention. Metal‐organic frameworks (MOFs) are a promising class of materials for enzyme immobilization carriers due to their appealing features, including a high specific surface area, high specific porosity, a stable framework structure, and a wide variety of functional sites. Due to the protection provided to enzymes by MOFs, several reported MOFs‐lipase composites display exceptional catalytic characteristics relative to free lipases. This includes increased enzyme efficiency, stability, selectivity, and recyclability. Herein, we summarize an updated review of the most recent advances in MOFs immobilizing lipases. This review sheds light on the numerous aspects of lipase‐MOF immobilization, with special emphasis on different techniques of designing lipase‐MOF platforms and the advantages of lipase‐MOF composites. Subsequently, molecular simulation approaches in lipase‐MOF immobilization are briefly introduced. Moreover, practical applications of MOFs‐lipase composites have been outlined. Finally, potential limitations and future directions for MOFs‐lipase immobilization research are highlighted.
Funder
National Natural Science Foundation of China
Beijing Municipal Natural Science Foundation
Beijing Municipal Commission of Education