Effect of diabetes mellitus on association between galectin‐3 and H2FPEF score in patients with unexplained dyspnea and a preserved left ventricular ejection fraction

Abstract

AbstractObjectivesThe aim of this study was to investigate the effect of diabetes mellitus (DM) on the association between Galectin‐3 (Gal‐3) and the H2FPEF score in patients with unexplained dyspnea and a preserved left ventricular ejection fraction (LVEF).MethodsA cross‐sectional observational study was conducted on patients with unexplained dyspnea and a preserved LVEF in the Cardiology Department of Elazıg Medical Park Hospital, Turkey. The patients were evaluated based on the presence of DM and the H2FPEF score. Gal‐3 levels were compared between groups, and the effect of DM on Gal‐3 was assessed. The level of statistical significance in all tests was set at p < .05.ResultsGal‐3 and H2FPEF scores were higher in patients with DM (p < .001 and p = .027, respectively). Gal‐3 and HbA1C values were elevated in patients with moderate to high H2FPEF scores (p < .01 and p = .036, respectively). DM and Hypertension were more prevalent in patients with moderate to high H2FPEF scores (p = 0.024, p < 0.001, respectively). A strong correlation was observed between Gal‐3 and the H2FPEF score (r = 0.375, p < .001). Gal‐3 could predict patients with a moderate to high H2FPEF score using a cut‐off value of 14.7, with a sensitivity of 69% and specificity of 67% (AUC: 0.702).ConclusionsGal‐3 serves as an independent predictor of the H2FPEF score in the presence of DM, and the diagnostic capability of Gal‐3 for Heart Failure with preserved LVEF remains unaffected by DM.