An eco‐friendly synthesis of 5‐aminotetrazoles using trichloroisocyanuric acid as desulfurization agent of thioureas

Author:

Moraes Adriana Marques1ORCID,da Silva Tiago Lima2ORCID,de Mattos Marcio C. S.1ORCID

Affiliation:

1. Departamento de Química Orgânica, Instituto de Química Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

2. Instituto Multidisciplinar de Química Universidade Federal do Rio de Janeiro Macaé Brazil

Abstract

AbstractA novel procedure for the preparation of various 5‐aminotetrazoles derivatives was achieved using trichloroisocyanuric acid as a desulfurizing agent of thioureas and trimethylsilyl azide in ethyl acetate at room temperature. This methodology provided substituted 5‐aminotetrazoles through a more sustainable reaction using an affordable, safe, stable, and easily handled N‐halo reagent, a safer azide source, and an environmentally friendly solvent.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Publisher

Wiley

Subject

Organic Chemistry

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