Affiliation:
1. Endocrinology and Metabolism Research Center (EMRC), Vali‐Asr Hospital Tehran University of Medical Sciences Tehran Iran
2. Department of Biology, Kerman Branch Islamic Azad University Kerman Iran
Abstract
ABSTRACTAimTo investigate the association between vitamin D3 level and oxidative stress biomarkers such as Heat Shock Protein 70 (HSP70), ferric reducing ability of plasma (FRAP), advanced oxidation protein products (AOPP) and advanced glycation end products (AGEs) in patients with Type 2 diabetes.MethodIn this cross‐sectional study, 54 patients including 32 females and 22 males with a mean age of 54.92 ± 11.37 years with T2D attending the diabetes clinic from 2021 to 2022 were included. According to the average level of vitamin D in this population (14.91), they were divided into two groups with vitamin D ≤15 ng/mL and vitamin D >15 ng/mL. Multivariate regression analysis was conducted to evaluate the relationship between vitamin D and AOPP, HSP and FRAP parameters. The correlation between vitamin D and other variables was evaluated via the Pearson correlation test.ResultVitamin D level had a positive relation with FRAP (β = 0.32, p = 0.017) and HSP (β = 0.39, p = 0.003), but had a negative relation with AOPP (β = −0.30, p = 0.02). The level of 2hPP also had a negative relation with the level of vitamin D (β = −0.33, p = 0.03). There was not any relationship between the level of vitamin D and AGEs or other variables. After adjusting for multiple confounders for the multivariate regression model, HSP remained significant.ConclusionThis research indicates the relationship between vitamin D levels and oxidative stress biomarkers in patients with Type 2 diabetes.
Reference48 articles.
1. Vitamin D deficiency and type 2 diabetes
2. Status of Vitamin‐D in Diabetic Patients;Bayani M. A.;Caspian Journal of Internal Medicine,2014
3. Vitamin D Deficiency Is Associated With Insulin Resistance in Nondiabetics and Reduced Insulin Production in Type 2 Diabetics;Esteghamati A.;Hormone and Metabolic Research,2015
4. The effect of vitamin D deficiency state on oxidized low-density lipoprotein alteration in patients with type 2 diabetes
5. Association of Vitamin D With Insulin Resistance and β-Cell Dysfunction in Subjects at Risk for Type 2 Diabetes
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