Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products

Author:

Hashemi Nazanin1,Karimpour Reyhan Sahar1,Qahremani Reihane1,Seifouri Kiana1,Tavakoli Meraj1,Seyedi Seyed Arsalan1,Ghaemi Farahnaz2,Abbaszadeh Mahsa1,Esteghamati Alireza1,Nakhjavani Manouchehr1ORCID,Mirmiranpour Hossein1,Rabizadeh Soghra1

Affiliation:

1. Endocrinology and Metabolism Research Center (EMRC), Vali‐Asr Hospital Tehran University of Medical Sciences Tehran Iran

2. Department of Biology, Kerman Branch Islamic Azad University Kerman Iran

Abstract

ABSTRACTAimTo investigate the association between vitamin D3 level and oxidative stress biomarkers such as Heat Shock Protein 70 (HSP70), ferric reducing ability of plasma (FRAP), advanced oxidation protein products (AOPP) and advanced glycation end products (AGEs) in patients with Type 2 diabetes.MethodIn this cross‐sectional study, 54 patients including 32 females and 22 males with a mean age of 54.92 ± 11.37 years with T2D attending the diabetes clinic from 2021 to 2022 were included. According to the average level of vitamin D in this population (14.91), they were divided into two groups with vitamin D ≤15 ng/mL and vitamin D >15 ng/mL. Multivariate regression analysis was conducted to evaluate the relationship between vitamin D and AOPP, HSP and FRAP parameters. The correlation between vitamin D and other variables was evaluated via the Pearson correlation test.ResultVitamin D level had a positive relation with FRAP (β = 0.32, p = 0.017) and HSP (β = 0.39, p = 0.003), but had a negative relation with AOPP (β = −0.30, p = 0.02). The level of 2hPP also had a negative relation with the level of vitamin D (β = −0.33, p = 0.03). There was not any relationship between the level of vitamin D and AGEs or other variables. After adjusting for multiple confounders for the multivariate regression model, HSP remained significant.ConclusionThis research indicates the relationship between vitamin D levels and oxidative stress biomarkers in patients with Type 2 diabetes.

Publisher

Wiley

Reference48 articles.

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