Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin

Author:

Nath Kavindra1,Nelson David S.1,Heitjan Daniel F.2,Leeper Dennis B.3,Zhou Rong1,Glickson Jerry D.1

Affiliation:

1. Laboratory of Molecular Imaging, Department of Radiology, Perelman School of Medicine; University of Pennsylvania; Philadelphia PA USA

2. Department of Biostatistics and Epidemiology, Perelman School of Medicine; University of Pennsylvania; Philadelphia PA USA

3. Department of Radiation Oncology; Thomas Jefferson University School of Medicine; Philadelphia PA USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Spectroscopy,Radiology Nuclear Medicine and imaging,Molecular Medicine

Reference47 articles.

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2. Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification;Ben-Yoseph;J. Neurooncol,1998

3. Noninvasive real-time monitoring of intracellular cancer cell metabolism and response to lonidamine treatment using diffusion weighted proton magnetic resonance spectroscopy;Mardor;Cancer Res.,2000

4. 31P and 1H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan;Nath;NMR Biomed.,2013

5. Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport;Zhou;Acad. Radiol.,2001

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