Stereoselective Synthesis of (R)-3-Methylthalidomide by Piperidin-2-one Ring Assembly Approach

Author:

Yadav Shyam Raj1,Tiwari Vinay Shankar12,Haq Wahajul12

Affiliation:

1. Medicinal and Process Chemistry Division; CSIR-Central Drug Research Institute; Lucknow India

2. Academy of Scientific and Innovative Research; New Delhi India

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Pharmacology,Catalysis,Analytical Chemistry

Reference38 articles.

1. Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers;Blaschke;Arzneim Forsch,1979

2. Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide;Eriksson;Chirality,1995

3. Clinical pharmacology of thalidomide;Eriksson;Eur J Clin Pharmacol,2001

4. Enantioselective inhibition of TNF-alpha release by thalidomide and thalidomide-analogues;Wnendt;Chirality,1996

5. Identification of a primary target of thalidomide teratogenicity;Ito;Science,2010

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