Mutant IDH1 inhibits PI3K/Akt signaling in human glioma-Reference-Cited by-同舟云学术

Mutant IDH1 inhibits PI3K/Akt signaling in human glioma

Published:2014-04-25 Issue:16 Volume:120 Page:2440-2447
ISSN:0008-543X
Container-title:Cancer
language:en
Short-container-title:Cancer

Author:

Birner Peter¹²,Pusch Stefan¹³,Christov Christo⁴,Mihaylova Stiliana⁴,Toumangelova-Uzeir Kalina⁵,Natchev Sevdalin⁵,Schoppmann Sebastian F.⁶,Tchorbanov Andrey⁷,Streubel Berthold⁸,Tuettenberg Jochen⁹,Guentchev Marin⁹

Affiliation:

1. Department of Neuropathology, Institute of Pathology; Ruprecht-Karls-University Heidelberg; Heidelberg Germany

2. Clinical Institute of Pathology; Medical University of Vienna; Vienna Austria

3. Clinical Cooperation Unit Neuropathology; German Cancer Research Center (DKFZ); Heidelberg Germany

4. Department of Neurosurgery; St. Ivan Rilski Hospital; Sofia Bulgaria

5. Department of Neuropathology; St. Ivan Rilski Hospital; Sofia Bulgaria

6. Department of Surgery; Medical University of Vienna; Vienna Austria

7. Department of Immunology, Institute of Microbiology; Bulgarian Academy of Sciences; Sofia Bulgaria

8. Department of Obstetrics and Gynecology; Medical University of Vienna; Vienna Austria

9. Department of Neurosurgery; Klinikum Idar-Oberstein; Idar-Oberstein Germany

Publisher

Wiley

Subject

Cancer Research,Oncology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cncr.28732/fullpdf

Reference31 articles.

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2. IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo;Bralten;Ann Neurol.,2011

3. IDH mutation impairs histone demethylation and results in a block to cell differentiation;Lu;Nature.,2012

4. Targeting PI3K signalling in cancer: opportunities, challenges and limitations;Engelman;Nature Rev Cancer.,2009

5. PI3K Signaling in glioma-animal models and therapeutic challenges;Cheng;Brain Pathol.,2009

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