Forced Degradation of Betamethasone Sodium Phosphate under Solid State: Formation, Characterization, and Mechanistic Study of All Four 17,20-Diastereomers of Betamethasone 17-Deoxy-20-Hydroxy-21-Oic Acid

Author:

Li Min,Wang Xin,Chen Bin,Chan Tze-Ming,Rustum Abu

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference9 articles.

1. Application of LC-MSn in Conjunction with Mechanism-based Stress Studies in the Elucidation of Drug Impurity/Degradation Product Structures and Degradation Pathways;Li;Am Pharm Rev,2008

2. 17-Deoxygenation: a new pathway of Cotisol metabolism isolation of 17-deoxycortolonic acids;Weiss;J Clin Endocrinol Metab,1976

3. 11ß, 20-Dihydroxy-3-oxopregna-4, 17(20)-dien-21-al: an intermediate in the biological 17-dehydroxylation of Cortisol;Singer;Endocrinology,1986

4. A variation of Mattox rearrangement mechanism under alkaline condition;Li;Tetrahedron Lett,2007

5. Analysis of betamethasone, dexamethasone and related compounds by liquid chromatography/electrospray mass spectrometry;Arthur;Rapid Commun. Mass Spectrom,2004

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