Tau‐induced deficits in nonsense‐mediated mRNA decay contribute to neurodegeneration-Reference-Cited by-同舟云学术

Tau‐induced deficits in nonsense‐mediated mRNA decay contribute to neurodegeneration

Published:2022-04-13 Issue:2 Volume:19 Page:405-420
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Zuniga Gabrielle¹²³^ORCID,Levy Simon¹²³,Ramirez Paulino¹²³,De Mange Jasmine¹²³,Gonzalez Elias¹²³,Gamez Maria¹²³,Frost Bess¹²³

Affiliation:

1. Barshop Institute for Longevity and Aging Studies San Antonio Texas USA

2. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases San Antonio Texas USA

3. Department of Cell Systems and Anatomy University of Texas Health San Antonio San Antonio Texas USA

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/alz.12653

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1. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

2. Tau is a candidate gene for chromosome 17 frontotemporal dementia

3. Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies

4. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo

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